The Characteristics of Helicobacter pylori infection and Clinical Outcomes of Patient with Upper Gastrointestinal Bleeding Admitted at Hospital Universiti Sains Malaysia

Abstract

Upper gastrointestinal bleeding (UGIB) remains one of the most common clinical life threatening emergencies which are associated with a high morbidity and mortality. The main aim of this study was to determine the cause of Helicobacter pylori (H. pylori) infection and the use of non-steroidal anti-inflammatory drugs (NSAID) in upper gastrointestinal bleeding patients. A retrospective record review study was conducted among UGIB confirmed patients from January 2009 and December 2012 at Hospital Universiti Sains Malaysia. All patients who were admitted in hospital were recruited. Data collection included age, gender, Helicobacter pylori positivity, associated symptoms and Endoscopic findings. There were 46 patients with a mean age of 62 years. H. pylori was detected only in 2 (4.3%) both in Male among UGIB patients by Campylobacter-like organism (CLO) test. The prevalence of UGIB was higher in men than women 27(58.7%). The most common cause of UGIB was peptic ulcer (56.5%) and especially high amongst male patients (59.2%).The second common cause of UGIB was gastritis (19.6%). The majority of the patients are NSAID users 25 (54.3%). In conclusion, Peptic ulcer disease is the leading cause of UGIB and mainly common among males and H. pylori infection in upper gastrointestinal bleeding patients was low.