Abstract:
Upper gastrointestinal bleeding (UGIB) remains one of the most common clinical life threatening
emergencies which are associated with a high morbidity and mortality. The main aim of this study was to
determine the cause of Helicobacter pylori (H. pylori) infection and the use of non-steroidal anti-inflammatory
drugs (NSAID) in upper gastrointestinal bleeding patients. A retrospective record review study was conducted
among UGIB confirmed patients from January 2009 and December 2012 at Hospital Universiti Sains Malaysia.
All patients who were admitted in hospital were recruited. Data collection included age, gender, Helicobacter
pylori positivity, associated symptoms and Endoscopic findings. There were 46 patients with a mean age of
62 years. H. pylori was detected only in 2 (4.3%) both in Male among UGIB patients by Campylobacter-like
organism (CLO) test. The prevalence of UGIB was higher in men than women 27(58.7%). The most common
cause of UGIB was peptic ulcer (56.5%) and especially high amongst male patients (59.2%).The second common
cause of UGIB was gastritis (19.6%). The majority of the patients are NSAID users 25 (54.3%). In conclusion,
Peptic ulcer disease is the leading cause of UGIB and mainly common among males and H. pylori infection in
upper gastrointestinal bleeding patients was low.
