School of Nursing and Midwifery

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    The Characteristics of Helicobacter pylori infection and Clinical Outcomes of Patient with Upper Gastrointestinal Bleeding Admitted at Hospital Universiti Sains Malaysia
    (World Applied Sciences Journal, 2014) Osman, Hussein Ali; Hasan, Habsah; Suppian, Rapeah; Hamzah, Nor Aizal Che; Sharif, Sharifah Emilia Tuan; Majid, Noorizan Abdul; Zilfalil, Bin-Alwi
    Upper gastrointestinal bleeding (UGIB) remains one of the most common clinical life threatening emergencies which are associated with a high morbidity and mortality. The main aim of this study was to determine the cause of Helicobacter pylori (H. pylori) infection and the use of non-steroidal anti-inflammatory drugs (NSAID) in upper gastrointestinal bleeding patients. A retrospective record review study was conducted among UGIB confirmed patients from January 2009 and December 2012 at Hospital Universiti Sains Malaysia. All patients who were admitted in hospital were recruited. Data collection included age, gender, Helicobacter pylori positivity, associated symptoms and Endoscopic findings. There were 46 patients with a mean age of 62 years. H. pylori was detected only in 2 (4.3%) both in Male among UGIB patients by Campylobacter-like organism (CLO) test. The prevalence of UGIB was higher in men than women 27(58.7%). The most common cause of UGIB was peptic ulcer (56.5%) and especially high amongst male patients (59.2%).The second common cause of UGIB was gastritis (19.6%). The majority of the patients are NSAID users 25 (54.3%). In conclusion, Peptic ulcer disease is the leading cause of UGIB and mainly common among males and H. pylori infection in upper gastrointestinal bleeding patients was low.
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    Clinical significance of Helicobacter pylori cagA and iceA genotype status
    (World Journal of Gastroenterology, 2010-09-21) Amjad, Nasser; Osman, Hussain Ali; Razak, Najibah Abdul; Kassian, Junaini; Din, Jeffri; bin Abdullah, Nasuruddin
    To study the presence of Helicobacter pylori (H. pylori ) virulence factors and clinical outcome in H. pylori infected patients.
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    Prevalence of Helicobacter pylori cagA, babA2, and dupA genotypes and correlation with clinical outcome in Malaysian patients with dyspepsia
    (Turkish Journal of Medical Sciences, 2014-12-20) OSMAN, Hussein Ali; HASAN, Habsah; SUPPIAN, Rapeah; HASSAN, Syed; ANDEE, Dzulkarnaen Zakaria; MAJID, Noorizan ABDUL; ZILFALIL, Bin-Alwi
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    Genotyping of Helicobacter pylori cagA Gene from a Patient Who Failed Eradication Therapy: A Case Report and Review of the Literature
    (International Medical Journal, 2015-04-01) Osman, Hussein Ali; Hasan, Habsah; Suppian, Rapeah; Arjunan, Saravanan; B. A., Zilfalil
    Helicobacter pylori (H. pylori) is a bacterium that causes chronic gastritis, gastric and duodenal ulcers and gastric cancer. Here we report a female patient presenting with dyspepsia. She was tested positive six times by the Rapid Urease test and Urea breath test (UBT). A culture of gastric biopsy was done and the isolate showed resistance to Clarithromycin and Metronidazole while polymerase chain reaction (PCR) revealed the presence of cagA H. pylori virulence gene. Presence of cagA might not be a risk factor in development of Metronidazole resistance to antibiotic therapy. In conclusion, we report a female Malaysian Indian with cagA positive H. pylori infection, but experienced Metronidazole resistance to antibiotic therapy.
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    DETECTION OF HELICOBACTER PYLORICagAAND VacA GENOTYPES FROM STOOL SPECIMEN AMONG INFECTED AND ASYMPTOMATIC HEALTHY INDIVIDUALS
    (EAST AFRICAN MEDICAL JOURNAL, 2016-09-01) Osman, H. A.
    Helicobacter pylori(H. Pylori) is one of the most common pathogens affecting human kind, infecting more than 50% of the world's population. Invasive and non-invasive methods have been used to diagnose H. pylori infection. The polymerase chain reaction (PCR) has been broadly and successfully used to detect Helicobacter pylori virulence genes in gastric biopsies and stool specimen due to its high sensitivity and specificity. Genotyping using H. pylori genes, the cytotoxin associated gene A (cagA) and voculating cytotoxin gene A (vacA), offers one of the best options. Objective: To determine if genotyping of H. pylori cytotoxin associated gene A (cagA) and voculating cytotoxin gene A (vacA) virulence genes in infected patients as well as healthy individuals can be done from stool specimen. Study selection: A Pubmed/Medline search was carried out using specific key words to retrieve all publications on genotyping of H. pylori cagA and vacA from stool specimen between year 2003 to 2012. Data synthesis:Ten different studies from different locations fulfilled the selection criteria and were included in the study. Results:This review summarises different protocol used to successfully detect H.pylori virulence genes cytotoxin associated gene A (cagA) and voculating cytotoxin gene A (vacA) from faecal specimen by PCR from asymptomatic healthy individuals and infected people with Helicobacter pylori infection. Conclusion: this review highlights the use of stool specimen as an alternative test for genotyping of H. pylori cagA and vacA virulence genes as it is non-invasive and easy to collect.
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    A Global Survey of COVID-19 Vaccine Acceptance Among Healthcare Workers
    (Frontiers in Public Health, 2022-02-08) Noushad, Mohammed; Rastam, Samer; Nassani, Mohammad Zakaria; Al-Saqqaf, Inas Shakeeb; Hussain, Mudassir; Yaroko, Ali Ango; Arshad, Mohammed; Kirf, Abdullahi Musa; Koppolu, Pradeep; Niazi, Fayez Hussain; Elkandow, Ali; Darwish, Mahmoud; Nassar, Ahmad Salim Abdalla; Mohammed, Sami Osman Abuzied; Hassan, Nasser Hassan Abdalrady; Abusalim, Ghadah Salim; Samran, Abdulaziz; Alsalhani, Anas B; Demachkia, Amir Mohiddin; Marques de Melo, Renata; Luddin, Norhayati; Adam, Husein; Habib, Adnan; Suleyman, Firas; Osman, Hussein Ali; Al-Awar, Mohammed Sadeg; Dimashkieh, Mohiddin R.; Swapna, Lingam Amara; Barakat, Ali; Alqerban, Ali
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    Evaluation of the Atlas Helicobacter pylori Stool Antigen Test for Diagnosis of Infection in Adult Patients
    (Asian Pacific Journal of Cancer Prevention, 2014) HUSSEIN, ALI OSMAN; Habsah, Hasan; Rapeah, Suppian; Norhaniza, Bahar; Nurzam, Suhaila Che Hussin; Amry, Abdul Rahim; Syed, Hassan; Dzulkarnaen, Zakaria Andee; Bin-Alwi, Zilfalil
    Background: Helicobacter pylori (H.pylori) is one of the most important causes of dyspepsia and gastric cancer and diagnosis can be made by invasive or non-invasive methods. The Atlas Helicobacter pylori antigen test is a new rapid non-invasive method which is simple to conduct. The aim of this study was to determine its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. Materials and Methods: This prospective study was conducted between July 2012 and December 2013. Stool samples of 59 dyspeptic patients who underwent upper endoscopy were evaluated for H. pylori stool antigen. Results: From the 59 patients who participated in this study, there were 36 (61%) males and 23 (39%) females. H. pylori was diagnosed in 24 (40.7%) gastric biopsies, 22 (91.7 %) of these being positive for the Atlas H. pylori antigen test. The sensitivity, specificity, PPV, NPV and accuracy were 91.7%, 100%, 100%, 94.6% and 96.6% respectively. Conclusions: The Atlas H. pylori antigen test is a new non-invasive method which is simple to perform and avails reliable results in a few minutes. Thus it can be the best option for the diagnosis of H. pylori infection due to its high sensitivity and specificity.
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    Department of Nursing