Department of Nursing

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The Characteristics of Helicobacter pylori infection and Clinical Outcomes of Patient with Upper Gastrointestinal Bleeding Admitted at Hospital Universiti Sains Malaysia
(World Applied Sciences Journal, 2014) Osman, Hussein Ali; Hasan, Habsah; Suppian, Rapeah; Hamzah, Nor Aizal Che; Sharif, Sharifah Emilia Tuan; Majid, Noorizan Abdul; Zilfalil, Bin-Alwi
Upper gastrointestinal bleeding (UGIB) remains one of the most common clinical life threatening emergencies which are associated with a high morbidity and mortality. The main aim of this study was to determine the cause of Helicobacter pylori (H. pylori) infection and the use of non-steroidal anti-inflammatory drugs (NSAID) in upper gastrointestinal bleeding patients. A retrospective record review study was conducted among UGIB confirmed patients from January 2009 and December 2012 at Hospital Universiti Sains Malaysia. All patients who were admitted in hospital were recruited. Data collection included age, gender, Helicobacter pylori positivity, associated symptoms and Endoscopic findings. There were 46 patients with a mean age of 62 years. H. pylori was detected only in 2 (4.3%) both in Male among UGIB patients by Campylobacter-like organism (CLO) test. The prevalence of UGIB was higher in men than women 27(58.7%). The most common cause of UGIB was peptic ulcer (56.5%) and especially high amongst male patients (59.2%).The second common cause of UGIB was gastritis (19.6%). The majority of the patients are NSAID users 25 (54.3%). In conclusion, Peptic ulcer disease is the leading cause of UGIB and mainly common among males and H. pylori infection in upper gastrointestinal bleeding patients was low.
Clinical significance of Helicobacter pylori cagA and iceA genotype status
(World Journal of Gastroenterology, 2010-09-21) Amjad, Nasser; Osman, Hussain Ali; Razak, Najibah Abdul; Kassian, Junaini; Din, Jeffri; bin Abdullah, Nasuruddin
To study the presence of Helicobacter pylori (H. pylori ) virulence factors and clinical outcome in H. pylori infected patients.
Genotyping of Helicobacter pylori cagA Gene from a Patient Who Failed Eradication Therapy: A Case Report and Review of the Literature
(International Medical Journal, 2015-04-01) Osman, Hussein Ali; Hasan, Habsah; Suppian, Rapeah; Arjunan, Saravanan; B. A., Zilfalil
Helicobacter pylori (H. pylori) is a bacterium that causes chronic gastritis, gastric and duodenal ulcers and gastric cancer. Here we report a female patient presenting with dyspepsia. She was tested positive six times by the Rapid Urease test and Urea breath test (UBT). A culture of gastric biopsy was done and the isolate showed resistance to Clarithromycin and Metronidazole while polymerase chain reaction (PCR) revealed the presence of cagA H. pylori virulence gene. Presence of cagA might not be a risk factor in development of Metronidazole resistance to antibiotic therapy. In conclusion, we report a female Malaysian Indian with cagA positive H. pylori infection, but experienced Metronidazole resistance to antibiotic therapy.