A new sesquiterpenoid from the rhizomes of Homalomena sagittifolia
Date
2012-05
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis
Abstract
A new sesquiterpenoid, 1 ,4 ,7 -eudesmanetriol (1), was isolated together with the known compounds 1 ,4 ,7 -eudesmanetriol (2) and oplopanone (3) from the rhizomes of Homalomena sagittifolia. The structures of these compounds were determined by extensive spectral analyses. The compounds 1 and 2 inhibited growth of Pseudomonas stutzeri with a MIC value of 117 mM when evaluated for antibacterial activity using the minimum concentration assay. Both these compounds showed remarkable activities against acetylcholinesterase enzyme with IC50 values ranging between 25 and 26 mM. The isolation of these sesquiterpenoids and their biological
activities observed in this study support the reported traditional uses of H. sagittifolia for the treatment of microbial related diseases and central nervous system disorders.
Description
Keywords
Homalomena sagittifolia, Araceae, Sesquiterpenoids, Antibacterial activity, Acetylcholinesterase