(International Medical Journal, 2015-04-01) Osman, Hussein Ali; Hasan, Habsah; Suppian, Rapeah; Arjunan, Saravanan; B. A., Zilfalil
Helicobacter pylori (H. pylori) is a bacterium that causes chronic gastritis, gastric and duodenal ulcers and gastric cancer.
Here we report a female patient presenting with dyspepsia. She was tested positive six times by the Rapid Urease test and Urea
breath test (UBT). A culture of gastric biopsy was done and the isolate showed resistance to Clarithromycin and Metronidazole
while polymerase chain reaction (PCR) revealed the presence of cagA H. pylori virulence gene. Presence of cagA might not be a
risk factor in development of Metronidazole resistance to antibiotic therapy. In conclusion, we report a female Malaysian Indian
with cagA positive H. pylori infection, but experienced Metronidazole resistance to antibiotic therapy.
