Microbiology and Nursing Research

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    Prevalence of Helicobacter pylori cagA, babA2, and dupA genotypes and correlation with clinical outcome in Malaysian patients with dyspepsia
    (Turkish Journal of Medical Sciences, 2014-12-20) OSMAN, Hussein Ali; SUPPIAN, Rapeah; HASSAN, Syed; ANDEE, Dzulkarnaen Zakaria; MAJID, Noorizan ABDUL; ZILFALIL, Bin-Alwi
    The severity of disease outcome in dyspepsia has been attributed to Helicobacter pylori virulence genes. The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, and dupA) and to determine whether or not there arises a significant correlation with clinical dyspepsia outcomes.
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    Genotyping of Helicobacter pylori cagA Gene from a Patient Who Failed Eradication Therapy: A Case Report and Review of the Literature
    (2015-04-01) Osman, Hussein Ali; Hasan, Habsah; Suppian, Rapeah; Arjunan, Saravanan; B. A., Zilfalil
    Helicobacter pylori (H. pylori) is a bacterium that causes chronic gastritis, gastric and duodenal ulcers and gastric cancer. Here we report a female patient presenting with dyspepsia. She was tested positive six times by the Rapid Urease test and Urea breath test (UBT). A culture of gastric biopsy was done and the isolate showed resistance to Clarithromycin and Metronidazole while polymerase chain reaction (PCR) revealed the presence of cagA H. pylori virulence gene. Presence of cagA might not be a risk factor in development of Metronidazole resistance to antibiotic therapy. In conclusion, we report a female Malaysian Indian with cagA positive H. pylori infection, but experienced Metronidazole resistance to antibiotic therapy.